澳门新葡亰平台游戏

细胞与分子生物学研究所

发布者:管理员发布时间:2018-05-07浏览次数:10

细胞与分子生物学研究所

细胞与分子生物学研究所成立于2006年,2008年被批准为武汉科技大学校级重点实验室。实验室主要有2个大的研究领域,一是将电生理技术与分子生物学技术相结合,形成了心脏电生理研究、心肌力学和细胞膜离子通道表达调控的研究方向。另外还重点研究Myocardin家族相关转录因子与其它调节因子相互作用对心脑血管疾病相关基因表达的调控,在基因转录水平探讨Myocardin家族相关转录因子对细胞增殖、分化和凋亡基因表达调控的分子机制。

目前本实验室10人,其中6人有博士学历,2位有海外留学和工作经历,2位实验室管理人员。在神经心脏电生理心肌力学和细胞膜离子通道表达调控研究方面处于国内领先水平。

研究方向:

1. 心血管生理学

2. 分子肿瘤生物学

3. 分子神经生物学

4. 脑血管疾病的分子生物学

5. 神经系统疾病

承担课题:

1. 国家自然科学基金面上项目(No.81571095),ICAM5RNA结合蛋白FMRP

   的动态关联机制及其对脆性X综合征树突棘成熟的影响,2016/1-2019/12

   69万,主持人:曾燕。

2. 国家自然科学基金面上项目(NO.31271199),TrkB激动剂7,8-dihydroxyflavone对脆性X综合征突触可塑和学习记忆的影响及机制,2013/1-2016/1287万,主持人:曾燕。

3. 湖北省卫生与计划生育委员会(NO.WJ2015MB050),端脑素(Telencephalin)RNA结合蛋白FMRP的动态关联对脆性X综合征神经元树突棘成熟的影响与机制,2015/03-2017/0310万,主持人:曾燕。

4. 武汉市科技攻关计划(NO2013060602010278),7,8-dihydroxyflavone对阿尔茨海默病学习记忆的改善作用研究,30,主持人:曾燕。

5. 国家科技部863计划益生菌定向筛选与功能开发关键技术的研究No: 2008AA10Z336

6. 国家自然科学基金面上项目组蛋白乙酰化和去乙酰化对MRTF-A抗脑缺血诱导神经细胞凋亡的影响及机制No31171327

7. 国家自然科学基金面上项目“MRTF-AERK1/2相互作用对脑缺血诱导的神经细胞凋亡的调节及其机制 No30873070

8. 湖北省省自然科学基金七叶皂苷钠PEG衍生物的制备及药动学研究 No2005ABA089

9. 湖北省教育厅重点项目烯丙基半胱氨酸抗动脉粥样硬化作用机理研究 No D200711001

10. 武汉市科技攻关项目专项桑叶黄酮降糖胶囊的临床前研究No

   20076032104

11. 国家科技支撑项目中成药二次综合开发研究No2006BAI06A19

12. 武汉市重点科技攻关项目子课题七叶皂苷脂质体的应用研究No 20056002050-125

科研成果:

1. Gao Lei, Tian Mi, Zhao Hong-Yun, Xu Qian-Qian, Huang Yu-Ming, Si Qun-Cao, Tian Qing, Wu Qing-Ming, Hu Xia-Min, Sun Li-Bo, McClintock SM, Zeng Yan*. TrkB activation by 7, 8-dihydroxy?avone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease.  Journal of Biochemistry, Accepted.

2. Tian Mi, Zeng Yan*, Hu Yilan, Yuan Xiuxue, Liu Shumin, Li Jie, Lu Pan, Sun Yao, Gao Lei, Fu Daan, Li Yi, McClintock SM. TrkB agonist 7, 8-dihydroxyflavone changes synapse expression of AMPA subunits and ameliorates behavioral and spine abnormalities in a mouse model of fragile X syndrome. Neuropharmacology. 2015; 89: 43-53.

3. Zeng Yan*, Wang Xiaonan, Wang Qiang, Liu Shumin, Hu Xiamin, McClintock SM. Small molecules activating TrkB receptor for treating a variety of CNS disorders. CNS Neurol Disord Drug Targets. 2013, 12(7):1066-77.

4. Zeng Yan*, Chang Wei, Shu Chang, Ma Lina, Huang Yuanyuan, Wang  Ruoshi, Zhang Junpeng, Zhu Changcai, McClintock SM. Decreased cognitive function in extended family members from the single late-onset-Alzheimer's-disease pedigree. J Int Neuropsychol Soc. 2013, 19(7):809-19. 

5. Zeng Yan*, Liu Yakun, Wu Mianyun, Liu Jun, Hu Qi. Activation of TrkB by 7, 8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. J Alzheimers Dis. 2012, 31(4):765-78.

6. Zeng Yan*, Lv Feng, Li Long, Yu Hui, Dong Min, Fu Qinghai. 7, 8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. J Neurochem. 2012, 122(4):800-11.

7. Wang J, Hu X. Ecopharmacovigilance: Current state, challenges, and opportunities in China. Indian J Pharmacol. 2014 Jan-Feb;46(1):13-7. 

8. Wang JChen SXu SYu XMa DHu X*, Cao X. In Vivo Induction of Apoptosis by Fucoxanthin, a Marine Carotenoid, Associated with Down-Regulating STAT3/EGFR Signaling in Sarcoma 180 (S180) Xenografts-Bearing Mice. Mar Drugs, 10(9):2055-68, 2012.

9. Gong WHZheng WXWang JChen SHPang BHu XM*, Cao XL. Coexistence of hyperlipidemia and acute cerebral ischemia/reperfusion induces severe liver damage in a rat model. World J Gastroenterol, 18(35):4934-4943, 2012.

10. Xiao-lu CAO, Xia-Min HU*, Jia-Qing HU, Wen-Xia ZHENG. Myocardin-related transcription factor-A promoting neuronal survival against apoptosis induced by hypoxia/ischemia. Brain Research 2011, 1385263-274.

11. Rui-xue Yu, Xia-min Hu*Shi-qiang Xu, Zheng-ju Jiang, Wen Yang. Effects of fucoxanthin on proliferation and apoptosis in human gastric adenocarcinoma MGC-803 cells via JAK/STAT signal pathway. European Journal of Pharmacology 2011, 657(1-3):10-19.

12. Hua-Feng Zhang, Xia-Min Hu*, Lan-Xin Wang, Shi-Qiang Xu, Fan-Dian Zeng. Protective Effects of Scutellarin against Cerebral Ischemia in Rats: Evidence for Inhibition of the Apoptosis-Inducing Factor Pathway. Planta Med 2009, 75(2):121-126.

13. Xia-Min HU, Shi-Zeng SONG, Fang-Li YE, Li-Wen LIU. High-Performance Liquid Chromatographic Determination of Urinary Trans, Trans-Muconic Acid Excreted by Workers Occupationally Exposed to Benzene. Biomedical and Environmental Science 2006, 8.292-296.

14. Xia-min HU*, Mi-mei ZHOU, Xian-min HU, Fan-dian ZENG. Neuroprotective effects of scutellarin on rat neuronal damage induced by cerebral ischemia/reperfusion. Acta Pharmacol Sin 2005, 26(12):1454-1459.

15. Xia-min HU*, Yan ZHANG, Fan-dian ZENG..Effects of sodium beta-aescin on expression of adhesion molecules and migration of neutrophils after middle cerebral artery occlusion in rats.Acta Pharmacol Sin 2004, 25(7):869-875.

16. Xia-min HU*, Yan ZHANG, Fan-dian ZENG. Effects of beta-aescin on apoptosis induced by transient focal cerebral ischemia in rats. Acta Pharmacol Sin 2004, 25(10):1267-12675.

17. Ma Ji-hua. Procaine, a State-Dependent Blocker, Inhibits HERG Channels by Helix Residue Y652 and F656 in the  S6 Transmembrane Domain. J Pharmacol Sci 2013.

18. Ma Ji-hua. Blockade of the human ether-a-go-go-related gene potassium channel by ketamine. J Pharm Pharmacol 2013.

19. Ma Ji-hua. Resveratrol Attenuates the Na+-Dependent Intracellula Ca2+ Overload by Inhibiting H2O2-Induced Increasein Late Sodium Currentin Ventricular Myocytes. PLoS ONE 2012.

20. Ma Ji-hua. The effect of ligustrazine on L-type calcium current, calcium transient and contractility in rabbit ventricular myocytes. J Ethnopharmacol 2012.

21. Ma Ji-hua. Sophocarpine Attenuates the Na+-dependent Ca2+ Overload Induced by Anemonia Sulcata Toxin II-increased Late Sodium Current in Rabbit Ventricular Myocytes. J Cardiovasc Pharmacol 2012.

22. Ma Ji-hua. Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes. Am J Physiol Cell Physiol 2012.

23. Ma Ji-hua. Persistent sodium current and Na(+)/H (+) exchange contributes to the augmentation of the reverse Na(+)/Ca (2+) exchange during hypoxia or acute ischemia in ventricular myocytes. Pflugers Arch - Eur J Physiol 2012

24. Ma Ji-hua. Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of IKr Inhibition on Ventricular Repolarization. Circulation 2011.

25. Ma Ji-hua. Increased intracellular calcium concentration causes electrical turbulences in guinea pig ventricular myocytes. Sci China Life Sci 2011.

26. Ma Ji-hua. Block effect of capsaicin on hERG potassium currents was enhanced by S6 mutation at Y652. European Journal of Pharmacology 2010.

 


Copyright 2011 武汉科技大学·医学院 版权所有地址:湖北省武汉市洪山区黄家湖大学城特1号

XML 地图 | Sitemap 地图